“Cytomegalovirus”, a typical human virus contains a typical presence of a protein that plays a vital role in turning the human brain tumors more aggressive and spreading with fast pace.

Researchers from the ‘California pacific Medical Center research Institute’ conducted a study that established these findings with the help of sufficient evidences. These research findings have also been published in the journal “Cancer Research”.

A protein, “IE1” present in the human body, performs many functions altogether. It modifies the brain cancer cells in such a way that these cancerous cells start growing at fast pace. Researchers could establish a conformed performance of these cells for CMV in the “malignant process of this cancer”.

Tumor cells receive a ‘two-punch’ blow by the “IE1” protein. Researchers were able to trace out this ‘CMVIE1’ protein in almost every malignant brain tumor. This spotting led the researchers to say that “it can make tumor cells more aggressive by affecting two major pathways”.

The process has two stages. The first stage is for inhibiting two key tumor suppressing proteins within the brain tumor cells. During the second stage, there is a promotion of growth with pathway signals in the tumor itself. When both these cellular pathways are modulated the tumor cells get more agitated by the viral protein.

Dr. Charles Cobbs, the lead researcher, discovered an association of the CMV with the malignant brain tumors in the year 2002 .After almost seven years’ time identifying the mechanism for  helping the CMV tumor fuels, researchers have drawn up a projection which hopes to give an impetus to the development of new treatments in near future.

Dr.Liliana Soroceanu, the co-researcher in this study, is optimistic about the new opportunities opened up by this research. She foresees the strong possibilities of finding new ways to treat the malignant brain tumors with the development of new antiviral drugs in near future.”It would be “a simple oral medication that could dramatically help patients fight off a previously fatal cancer”, she says.

Most commonly, the brain cancer is represented by the high grade ‘glioma tumors’. It is difficult to treat such type of brain cancer as the surgical treatments do not stand as good options. Radiation therapies and chemotherapies have been proved to be of limited success only .This vulnerability increases the risk many times because the tumors grow with a tremendous speed and within a period of one year it becomes fatal.

CMV, a very common virus, is one of the main causes for persisting infection in almost 50% to 60% of the Americans. This disease displays very few symptoms and people at large are not much aware of these symptoms of infection.CMV could be a great risk factor even for the healthy individuals who have compromised immune system. Such a situation may be common with the people suffering through HIV/AIDs along with the organ transplant aspirants, and the pregnant women with their fetus.

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