The researchers who analyzed family histories of Alzheimer’s ascertained that a complete picture of overall risk couldn’t be got by the gene associated with Alzheimer’s disease.
In previous studies, it was shown that people with the E4 variant of the APOE gene had higher risk of the disease. However, this new study led by new Duke University Medical centre was one among those few studies that investigated the role of family history as well as APOE.
Lead researcher Kathleen A. Welsh-Bohmer, who is director of Duke’s Bryan Alzhemier’s Research Centre, states in a news release “We have gathered that it is difficult to get the whole genetic story only with APOE genotype. To influence someone’s risk for developing Alzheimer’s there are other genes that may act independently of APOE.
In the study those more than 5,000 people were included who were 65 and above and enrolled in the study in 1995 in Cache County, Utah. Almost 3,000 of the participants provided details about their family history of the disease and DNA. These people were grouped to APOE E4 variant and family history of Alzheimer’s.
More than seven years’ average observation, it was found that people with family history of the disease and one or more copies of APOE E4 were experiencing a significant cognitive decline.
The study is going to be presented at the Alzheimer’s Association’s International Conference in Chicago on Tuesday.
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