The Yale University team, founds that use of aspirin can reduce the death risk in mice given a paracetamol overdose.

The phenomenon behind, it intercepts the chemical pathway that initiate inflammation within the organ. However the use of aspirin for this purpose in human is not known.

Cases of liver cirrhosis are rising day by day in the UK. The major reason behind is the extensive use of alcohol or the paracetamol overdose that contribute to more than hundred death per year.

Scientists are trying to find out the reason of liver damage due to paracetamol and alcohol. They also working on the start of chain reaction, triggered after the onset of inflammation caused by these two chemicals. The inflammation represents the high degree of liver damage.

In this latest research, scientists found that the death rate can be minimized in the mice being given with high dose of paracetamol, if a small dose of aspirin is also given.

The researchers believe that aspirin blocks the chemical receptors of liver that stimulate the inflammatory response.

Scientist have separated specific molecules called tool-like receptors antagonists, which can also block the receptors of liver, but aspirin is far cheaper than the isolated chemical that make it a useful therapy.

“Nothing till to date has been clinically proven to protect the liver from alcohol abuse. We also recommend that you should consult your doctor first for the long term use of aspirin.”

NHS Direct warns that, long term use of aspirin, without precaution can cause irritate inner walls of the stomach and a higher risk of bleeding and ulceration.

Many such specific epidemiological studies conducted in past have been successful in demonstrating the existing links between self-reported health status and the risk for death. More recently, it is for the first time that the researchers have linked health perception with HDL-C levels in the elderly.

In order to determine whether the same relationship exists in other age groups, Sissel Tomten at the “Norwegian School of Sport and Physical Education, Oslo, Norway”, and Arne Host mark at the “University of Oslo, Norway”, conducted a detailed research study recently. Findings of this study along with the complete analysis and data have recently been published in the “International Journal of Medical Sciences”.

Sissel Tomten and Arne Hostmark and their research team assessed patient-reported health status and lipid profile in 18,770 individuals aged 30-76 years who were participating in the Oslo Health Study.

Researchers observed that for all the age groups, the higher an individual’s HDL-C level was, the better they considered their health. Each 1 mmol/l (38.7 mg/dl) increase in HDL-C concentration increased the likelihood of a perception of “good health” for almost 2.27 times.
Researchers interestingly noted that importantly, this relationship was unaffected by factors such as gender, time since food intake, use of cholesterol-lowering drugs, chronic diseases, pain, psychological distress, smoking, alcohol, length of education, and diet.

“There seems to be a consistent association between HDL-C and self-reported health, as observed in many age groups and in both sexes,” said Sissel Tomten of the “Norwegian School of Sport and Physical Education, Oslo, Norway”, in the published study report.
Arne Høstmark at the “University of Oslo, Norway concludes in the published study report, “We were not able to obliterate the association by controlling for a large number of potentially confounding factors”.

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